Agrian-wild  Opuntia dillenii Fruit Extract can Ameliorative Cd Induced Hepatic Anomalies

Khawaja Raees Ahmad; Amin Ullah Shah Amin; Nabila Aziz

Agrian-wild Opuntia dillenii Fruit Extract can Ameliorative Cd Induced Hepatic Anomalies

Authors

Khawaja Raees Ahmad 1. Assistant Professor of Zoology, University of Sargodha, Pakistan
Amin Ullah Shah Amin Assistant Professor of Botany, University of Sargodha, Pakistan
Nabila Aziz Assistant Professor of Botany, University of Sargodha, Pakistan

Keywords:

ameliorative, , hepatic anomalies, , hepatocytes,, histopathological,, hepatoblast

Abstract

Wild Opuntia dillenii, a spiny pest pear, is a cactus native to tropical and subtropical deserts and semi-desert land. It is completely ignored by farmers and researchers due to its prickly and spiny nature, but its flowers, reddish-purple fruit, and latex have potent medicinal values. The present research article evaluates the ameliorative role of Opuntia dillenii fruit extract (OFE) against cadmium (Cd) induced hepatic anomalies in mice. Thirty albino mice (Mus musculus) were randomly equally grouped as C; Control, Cd; 50ppm Cd in drinking water for 15 days after followed withdrawal and Cd+OFE; (Cd +Opuntia dillenii) treated as Cd but additionally post-treatment by 0.2ml/12h OFE for next 7 days. Recoveries were made on the 23^rdday of the experiment, and the liver was separated, weighed, and processed for further histopathological studies. Cd treated has irregular hepatocytes with large nuclei, steatosis and apoptotic cells with debris make constricted sinusoid spaces. There was a significant reduction of the number per unit area and cross-sectional area (CSA) of the hepatocytes with elevated (P<0.05) CSA of the central lobular vein. These pathological signs were convincingly recovered and regenerating hepatoblasts potential was dominant in the Cd+OFE group indicating the rescuing potential. These findings indicate the hepatoprotective role of the O.dillenii fruit extract on the hepatohistopathological changes of Cd exposure indicating their hepatoprotective medicinal importance for similar possible human benefits.

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Agrian-wild Opuntia dillenii Fruit Extract can Ameliorative Cd Induced Hepatic Anomalies